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( A-E ) In the DSS-based αCTLA-4-induced colitis model, anti-mouse IL-17A neutralizing antibody (200 μg/mouse) was administered intraperitoneally at D0, D3, D6, and D9 (n=5). Body weight monitoring (A), DAI score monitoring (A), colon length measurement (B), endpoint tumor volume (C) and tumor weight (D) detection, representative colon H&E results and pathological score statistics (E). ( F-I ) In the DSS-based αCTLA-4-induced colitis model, <t>MK2206</t> (p.o.; 30 mg/kg/day), Rapamycin (i.p.; 5 mg/kg/day), and 2-DG (i.p.; 500 mg/kg/day) were administered from D0 to D10 (n=6). Body weight monitoring (F), DAI score monitoring (F), colon length measurement (G), endpoint tumor volume (H) and tumor weight (H) detection, representative colon H&E results and pathological score statistics (I). The data are presented as the mean ± SEM. ** p < 0.01; *** p < 0.001; ns not significant by one-way ANOVA followed by Tukey’s multiple comparisons test.
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( A-E ) In the DSS-based αCTLA-4-induced colitis model, anti-mouse IL-17A neutralizing antibody (200 μg/mouse) was administered intraperitoneally at D0, D3, D6, and D9 (n=5). Body weight monitoring (A), DAI score monitoring (A), colon length measurement (B), endpoint tumor volume (C) and tumor weight (D) detection, representative colon H&E results and pathological score statistics (E). ( F-I ) In the DSS-based αCTLA-4-induced colitis model, MK2206 (p.o.; 30 mg/kg/day), Rapamycin (i.p.; 5 mg/kg/day), and 2-DG (i.p.; 500 mg/kg/day) were administered from D0 to D10 (n=6). Body weight monitoring (F), DAI score monitoring (F), colon length measurement (G), endpoint tumor volume (H) and tumor weight (H) detection, representative colon H&E results and pathological score statistics (I). The data are presented as the mean ± SEM. ** p < 0.01; *** p < 0.001; ns not significant by one-way ANOVA followed by Tukey’s multiple comparisons test.

Journal: bioRxiv

Article Title: CTLA-4 inhibitors drive colitis through metabolic reprogramming-mediated Treg/Th17 imbalance

doi: 10.64898/2026.01.20.700699

Figure Lengend Snippet: ( A-E ) In the DSS-based αCTLA-4-induced colitis model, anti-mouse IL-17A neutralizing antibody (200 μg/mouse) was administered intraperitoneally at D0, D3, D6, and D9 (n=5). Body weight monitoring (A), DAI score monitoring (A), colon length measurement (B), endpoint tumor volume (C) and tumor weight (D) detection, representative colon H&E results and pathological score statistics (E). ( F-I ) In the DSS-based αCTLA-4-induced colitis model, MK2206 (p.o.; 30 mg/kg/day), Rapamycin (i.p.; 5 mg/kg/day), and 2-DG (i.p.; 500 mg/kg/day) were administered from D0 to D10 (n=6). Body weight monitoring (F), DAI score monitoring (F), colon length measurement (G), endpoint tumor volume (H) and tumor weight (H) detection, representative colon H&E results and pathological score statistics (I). The data are presented as the mean ± SEM. ** p < 0.01; *** p < 0.001; ns not significant by one-way ANOVA followed by Tukey’s multiple comparisons test.

Article Snippet: In the DSS-based αCTLA-4-induced colitis model, MK2206 (p.o.; 30 mg/kg/day; HY-108232, MCE), Rapamycin (i.p.; 5 mg/kg/day; HY-10219, MCE), and 2-DG (i.p.; 500 mg/kg/day; HY-13966, MCE) were administered from D0 to D10.

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